State Highway 5 is closed near Taupo following a serious crash.

Emergency services are responding to a serious crash between the cross roads of High Level Road and Wairango Road at Iwitahi.

The two-vehicle crash, involving a truck and a ute, was reported to police just after 6am, says a police spokesperson.

"Four people are reported to be injured - two people have serious injuries and two with moderate injuries.

"The road is expected to be closed for a period of time and motorists are asked to avoid the area or expect delays."